I am about to start again on Contrave, which worked well for me. It's a mix of buproprion and naltrexone, and I believe one of the reasons it worked for me is that I have a noticeable (to me) OCD component of overeating.

I stopped because the pandemic stopped my visits to the clinic that was prescribing it and my primary didn't want to prescribe it because she thought it was too dangerous/strong. I suspect she was freaked by the naltrexone component. However, my specialist doctor (same office as I got it from before) said it is approved for very long time use, so armed with that information, if I need to chivvy a primary care dr again (unlikely unless another pandemic) I will be prepared.